An internationally recognized expert in the mechanisms of neurodegenerative diseases, Dr. Dale Bredesen’s career has been guided by a simple idea: that Alzheimer’s as we know it is not just preventable, but reversible. Dr. Bredesen’s dedicated pursuit of the science that makes this a reality has placed him at the vanguard of neurological research and led to the discoveries that today underlie the ReCODE Protocol™.
Dr. Bredesen earned his M.D. from Duke University Medical Center and served as Chief Resident in Neurology at the University of California, San Francisco (UCSF), before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA, and the University of California, San Diego. Dr. Bredesen also directed the Program on Aging at the Burnham Institute before joining the Buck Institute in 1998 as the founding President and CEO.
Dr. Bredesen’s research explores previously uncharted territory in explaining the physical mechanism behind the erosion of memory seen in Alzheimer’s disease, and has opened the door to new approaches to treatment. This work has led to the identification of several new therapeutic processes that are showing remarkable early results. Dr. Bredesen is a prodigious innovator in medicine, with over thirty patents to his name. Notably, he put much of his findings and research into the 2017 New York Times bestseller, The End of Alzheimer’s.
His most recent book, The Ageless Brain, presents a revolutionary new approach to preventing the onset of neurodegenerative disease and creating sustained brain health.
David Perlmutter, M.D.
#1 New York Times Best Selling Author, Grain Brain and Brain Maker
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Publications
The Bredesen Protocol® is based on over thirty years of Dr. Bredesen’s laboratory research, which has resulted in hundreds of peer-reviewed publications that have uncovered the biochemical mechanisms behind the erosion of memory associated with Alzheimer’s disease.
Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project
A proof-of-concept clinical trial of a precision medicine protocol in 25 patients with mild cognitive impairment or early Alzheimer’s disease demonstrated that personalized evaluation and targeted treatment of multiple contributors to cognitive decline.
Reversal of Cognitive Decline: 100 Patients
Report of 100 patients, treated by several different physicians, with documented improvement in cognition, in some cases with documentation of improvement in electrophysiology or imaging, as well. This additional report provides further support for a randomized, controlled clinical trial of the protocol and the overall approach.
Reversal of cognitive decline in Alzheimer’s disease
This paper includes the first description of the reversal of cognitive decline in patients with early Alzheimer’s disease or its precursors, MCI (mild cognitive impairment) and SCI (subjective cognitive impairment).
Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease
Dr. Bredesen and his team showed that ApoE4 acts as a transcription factor and binds to the promoters of genes involved in a range of processes linked to aging and Alzheimer’s disease pathogenesis. These findings point to novel therapeutic strategies for Alzheimer’s disease and aging, resulting in an extension of human healthspan and a disease-free and functional period of life.
Live Talks
Dr. Bredesen regularly lectures and provides educational seminars worldwide to share his approach to ending the global burden of dementia. If you would like to invite Dr. Bredesen to speak at an event, please email media@ahnphealth.com.
TEDx ManhattanBeach
See Dr. Bredesen’s TedX talk, “A Precision Approach to End Alzheimer’s Disease,” given at Manhattan Beach. In this presentation, Dr. Bredesen shares his belief that this will be the last generation to fear Alzheimer’s and details how a precision approach to treatment can reverse cognitive decline.
Books
Dr. Bredesen has written several books, including two New York Times Bestsellers, that have forever changed the way we perceive the scourge of Alzheimer’s disease. His most recent book, The Ageless Brain, presents a revolutionary new approach to preventing the onset of neurodegenerative disease and creating sustained brain health.
